Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges
نویسندگان
چکیده
منابع مشابه
Cryoprotection-lyophilization and physical stabilization of rifampicin-loaded flower-like polymeric micelles.
Rifampicin-loaded poly(ε-caprolactone)-b-poly(ethylene glycol)-poly(ε-caprolactone) flower-like polymeric micelles display low aqueous physical stability over time and undergo substantial secondary aggregation. To improve their physical stability, the lyoprotection-lyophilization process was thoroughly characterized. The preliminary cryoprotectant performance of mono- and disaccharides (e.g. ma...
متن کاملRational design of Polymeric Hybrid Micelles to Overcome Lymphatic and Intracellular Delivery Barriers in Cancer Immunotherapy
Poor distribution of antigen/adjuvant to target sites and inadequate induction of T cell responses remain major challenges in cancer immunotherapy because of the lack of appropriate delivery systems. Nanocarrier-based antigen delivery systems have emerged as an innovative strategy to improve vaccine efficacy. Here we present polymeric hybrid micelles (PHMs) as a simple and potent antigen/adjuva...
متن کاملSupply chain challenges in public distribution system
The paper aims to discuss supply chain management challenges in Public Distribution System, a food security scheme in India, based on the data collected from the stakeholders. With particular focus on supply chain strategy, we explore how the social objectives lead to supply chain design which affect system’s performance.
متن کاملSupply Chain Performance Evaluation: Trends and Challenges
Problem statement: In today’s manufacturing world, globalization policies and rejuvenation have created a more intensive competition amongst manufacturers. On the other hand, manufacturers have turned to the option of adopting innovative technologies, process re-engineering and strategies such as efficient supply chain management to achieve a sustainable competitive advantage. Effective supply ...
متن کاملSupply Chain Integration: Challenges and Solutions
Since its introduction by management consultants in the early 1980s, supply chain management (SCM) has been primarily concerned with the integration of processes and activities both within and between organisations. The concept of supply chain integration (SCI) is based on documented evidence that suggests that much of the waste throughout businesses is a consequence of fragmented supply chain ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biotechnology Journal
سال: 2021
ISSN: 1860-6768,1860-7314
DOI: 10.1002/biot.202000212